histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-remodeling factor subunit RBAP48 (RBBP4, RbAp48)
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Function
- core histone-binding subunit
- may target chromatin assembly factors, chromatin remodeling factors & histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA
- component of several complexes which regulate chromatin metabolism
- component of the DREAM complex (LINC complex)
- interacts with SUV39H1 & HDAC7 (putative)
- binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin
- interacts with the viral protein-binding domain of the retinoblastoma protein (RB1)
- interacts with SPEN/MINT
- interacts with BRCA1
- interacts with CREBBP, & this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP
Structure
- belongs to the WD repeat RBAP46/RBAP48/MSI1 family
- contains 6 WD repeats
Compartment
More general terms
Component of
- chromatin assembly factor 1 (CAF-1)
- histone deacetylase (HDAC) core complex
- nucleosome remodeling & histone deacetylation (NuRD) complex
- Polycomb group multiprotein PRC2 complex; PRC2/EED-EZH2 complex; EZH2 histone methyltransferase complex (PcG)
- nucleosome-remodeling factor complex (NuRF complex)
- DREAM complex (LINC complex)