DREAM complex (LINC complex)

Function

• complex exists in quiescent cells where it represses cell cycle-dependent genes
• it dissociates in S phase when LIN9, LIN37, LIN52 & LIN54 form a subcomplex that binds to MYBL2
• can both act as a transcription activator or repressor depending on the context
• in G0 phase, the complex binds to more than 800 promoters & is required for repression of E2F target genes
• in S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis & participates in their cell cycle dependent activation

Structure

• subunits: E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBBP4, RBL2, TFDP1 & TFDP2

More general terms

• molecular complex