Lin-9 homolog (huLin-9, hLin-9, beta-subunit associated regulator of apoptosis, type 1 interferon receptor beta chain-associated protein, TUDOR gene similar protein, pRB-associated protein, LIN9, BARA, TGS)

Function

• acts as a tumor suppressor
• inhibits DNA synthesis
• ability to inhibit oncogenic transformation is mediated through association with RB1
• role in the expression of genes required for G1/S transition
• interacts with RB1

Structure

belongs to the lin-9 family

Compartment

• nucleus, nucleoplasm
• found in perinucleolar structures
• associated with chromatin

Alternative splicing

named isoforms=3

Expression

expressed in thymus & testis

More general terms

• anti-oncoprotein (tumor suppressor protein)
• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5TKA1.html