transcription factor Dp-2; E2F dimerization partner 2 (TFDP2, DP2)

Function

• can stimulate E2F-dependent transcription
• binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication
• component of the DP2/E3F complex
• interacts with GMCL (putative)
• component of the DREAM complex

Structure

belongs to the E2F/DP family

Compartment

nucleus

Alternative splicing

• named isoforms=4
• additional isoforms seem to exist

Expression

• high levels in heart & skeletal muscle
• also found in placenta, kidney, brain, lung & liver.
• presence as well as the abundance of the different transcripts appear to vary significantly in different tissues & cell lines

More general terms

• transcription factor (TF)
• DNA-binding protein

Component of

• DP2/E2F complex
• DREAM complex (LINC complex)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7029
• OMIM: https://mirror.omim.org/entry/602160
• UniProt: http://www.uniprot.org/uniprot/Q14188.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7029