desmoplakin (desmoplakin 1 & desmoplakin 2); 250/210 kD paraneoplastic pemphigus antigen (DSP)

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Function

Structure

Compartment

Alternative splicing

2 variants: desmoplakin 1 & desmoplakin 2

Expression

  • desmoplakin 1 is apparently an obligate constituent of all desmosomes
  • desmoplakin 2 is found predominantly in tissues & cells of stratified origin

Pathology

Genetics

gene locus 6p24

More general terms

More specific terms

Component of

References

  1. Green KJ et al Structure of the human desmoplakins. Implications for function in the desmosomal plaque. J Biol Chem 265:2603 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1689290
  2. UniProt http://www.uniprot.org/uniprot/P15924.html
  3. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=DSP
  4. Wikipedia; Note: desmoplakin entry http://en.wikipedia.org/wiki/desmoplakin

Database