involucrin (IVL)

Function

• part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia
• cytoskeletal protein cross-linked by transglutaminase
• may be involved in formation of a cytoskeletal cross-linked structure adjacent to the plasma membrane of squamous epithelia & in the formation of apoptotic cell bodies
• some Gln & Lysare cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin & envoplakin, & to lipids like omega-hydroxyceramide
• directly or indirectly cross-linked to cornifelin (CNFN)

Structure

belongs to the involucrin family

Compartment

• cytoplasm
• constituent of the scaffolding of the cornified envelope

Expression

• keratinocytes of epidermis & other stratified squamous epithelia

More general terms

• cytoskeletal protein
• oligomerizing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3713
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3713
• OMIM: https://mirror.omim.org/entry/147360
• UniProt: http://www.uniprot.org/uniprot/P07476.html