periplakin; 195 kD cornified envelope protein; 190 kD paraneoplastic pemphigus antigen (PPL, KIAA0568)

Function

• component of the cornified envelope of keratinocytes
• may link the cornified envelope to desmosomes & intermediate filaments
• may act as a localization signal in PKB/AKT-mediated signaling
• homodimer or a heterodimer with envoplakin (EVPL)
• interacts with PPHLN1 & VIM
• binds to the PH domain of AKT1
• interacts with FCGR1A

Structure

• belongs to the plakin or cytolinker family
• contains 2 plectin repeats
• contains 4 spectrin repeats

Compartment

• cell junction, desmosome
• cytoplasm, cytoskeleton
• cell membrane (putative)
• nucleus
• mitochondrion (putative)
• associated with desmosomes & intermediate filaments

Expression

• expressed in stratified squamous epithelia & in some other epithelia
• expressed during differentiation of epidermal keratinocytes

More general terms

• cytoskeletal protein
• oligomerizing protein
• antigen
• phosphoprotein

Additional terms

• desmosome
• intermediate filament
• keratinocyte

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5493
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5493
• OMIM: https://mirror.omim.org/entry/602871
• UniProt: http://www.uniprot.org/uniprot/O60437.html