periphilin-1 (gastric cancer antigen Ga50, PPHLN1)

Function

• role in epithelial differentiation
• contributes to epidermal integrity & barrier formation
• interacts with PPL
• substrate of transglutaminase (in vitro)

Structure

homodimer

Compartment

• nucleus, cytoplasm
• in undifferentiated keratinocytes, expressed in speckle-type nuclear granules & at nuclear membrane
• in differentiated keratinocytes, colocalized with periplakin at the cell periphery & at cell-cell junctions

Alternative splicing

named isoforms=8

Expression

ubiquitous

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608150
• UniProt: http://www.uniprot.org/uniprot/Q8NEY8.html