CD64; high affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI (FCGR1A, FCG1, FCGR1, IGFR1)

Function

• high affinity receptor binds to Fc region of IgG
• functions in both innate & adaptive immune responses
• phagocytosis & antigen presentation to T cells
• interacts with FCERG1; forms a functional signaling complex
• interacts with FLNA; prevents FCGR1A degradation
• interacts with EPB41L2, LAT & PPL
• phosphorylated on Ser (putative)

Structure

• N-glycosylated (putative)
• belongs to the immunoglobulin superfamily, FCGR1 family
• contains 3 Ig-like C2-type domain (immunoglobulin-like)

Compartment

• cell membrane
• stabilized at the cell membrane through interaction with FCER1G

Alternative splicing

named isoforms=2

Expression

• macrophages/monocytes
• activated granulocytes
• dendritic cells
• early myeloid cells

Pathology

• expressed in:
  • AML AML-M0, AML-M1, AML-M2 (variable), AML-M3 (usually), AML-M4, AML-M5

More general terms

• CD antigen
• Fc gamma receptor
• phosphoprotein

Additional terms

• filamin (actin-binding protein)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2209
• OMIM: https://mirror.omim.org/entry/146760
• UniProt: http://www.uniprot.org/uniprot/P12314.html