innate immunity
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Genetics
- genetic variations in TIRAP may influence susceptibility or resistance to invasive pneumococcal disease[2], malaria[3], & tuberculosis[4]
- genetic variations in TIRAP influence susceptibility or resistance to bacterial invasion of the blood & define the bacteremia susceptibility locus 1 (BACTS1)[5]
Physiology
mediated by
- antigen-independent, pattern recognition receptors
- Toll-like receptors
- surfactant (SP-A, SP-D)
- complement
- defensins
Laboratory
Mechanism of action
mediated by:
- antigen-independent, pattern recognition receptors
- Toll-like receptors
- surfactant (SP-A, SP-D)
- complement
- defensins
- in the brain astrocytes & microglia
More general terms
References
- ↑ Jump up to: 1.0 1.1 ARUP Consult: Immunodeficiency, Innate System, TLR-Signaling Defects The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/immunodeficiency-tlr-signaling-defects
- ↑ Jump up to: 2.0 2.1 OMIM https://mirror.omim.org/entry/610799
- ↑ Jump up to: 3.0 3.1 OMIM https://mirror.omim.org/entry/611162
- ↑ Jump up to: 4.0 4.1 OMIM https://mirror.omim.org/entry/607948
- ↑ Jump up to: 5.0 5.1 OMIM https://mirror.omim.org/entry/614382