pulmonary surfactant-associated protein D; PSP-D; SP-D; collectin-7; lung surfactant protein D (SFTPD, COLEC7, PSPD, SFTP4)

Function

• innate immune system collectin
• contributes to the lung's defense against inhaled microorganisms
• may participate in the extracellular reorganization or turnover of pulmonary surfactant
• binds strongly maltose residues & to a lesser extent other alpha-glucosyl moieties
• hydroxylation on Pro within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates (putative)
• interacts with DMBT1 & hemagglutinin of influenza A virus

Structure

• the N-terminus is blocked
• oligomeric complex of 4 set of homotrimers
• belongs to the SFTPD family
• contains 1 C-type lectin domain
• contains 1 collagen-like domain

Compartment

• secreted, extracellular space, extracellular matrix, surface film

Laboratory

• surfactant pulmonary-associated protein D in serum

More general terms

• secreted protein
• glycoprotein
• proteolipid

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6441
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6441
• OMIM: https://mirror.omim.org/entry/178635
• UniProt: http://www.uniprot.org/uniprot/P35247.html