envoplakin; 210 kD paraneoplastic pemphigus antigen; 210 kD cornified envelope protein; p210 (EVPL)

Function

• component of the cornified envelope of keratinocytes
• may link the cornified envelope to desmosomes & intermediate filaments
• substrate of transglutaminase
• some Glu & Lys are cross-linked to other envoplakin molecules, to other proteins such as keratin, desmoplakin, periplakin & involucrin, & to lipids like omega-hydroxyceramide
• may form a homodimer or a heterodimer with periplakin (PPL)

Structure

• belongs to the plakin or cytolinker family
• contains 7 plectin repeats
• contains 1 spectrin repeat

Compartment

• cell junction, desmosome, cornified envelope
• cytoplasm, cytoskeleton
• colocalized with DSP at desmosomes & along intermediate filaments

Expression

• exclusively expressed in stratified squamous epithelia
• expressed during differentiation of epidermal keratinocytes

More general terms

• cytoskeletal protein
• oligomerizing protein
• antigen
• phosphoprotein

Additional terms

• desmosome
• intermediate filament
• keratinocyte
• periplakin; 195 kD cornified envelope protein; 190 kD paraneoplastic pemphigus antigen (PPL, KIAA0568)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2125
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2125
• OMIM: https://mirror.omim.org/entry/601590
• UniProt: http://www.uniprot.org/uniprot/Q92817.html