transcription factor E2F5 (E2F-5, E2F5)

Function

• transcriptional activator
• binds to E2F sites present in the promoter of many genes whose products are involved in cell proliferation
• may mediate growth factor-initiated signal transduction
• role in the early responses of resting cells to growth factor stimulation
• component of the DRTF1/E2F transcription factor complex
• binds cooperatively with DP-1 to E2F sites
• interaction with retinoblastoma protein RB1 or proteins RBL1 & RBL2 inhibits the E2F transactivation domain
• component of the DREAM complex in quiescent cells

Structure

belongs to the E2F/DP family

Compartment

nucleus

More general terms

• E2F

Database

• UniProt: http://www.uniprot.org/uniprot/Q15329.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1875
• OMIM: https://mirror.omim.org/entry/600967
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1875