histone-binding protein RBBP7; retinoblastoma-binding protein 7; RBBP-7; retinoblastoma-binding protein p46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46 (RBBP7, RBAP46, HAT2)

Function

• core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases & histone deacetylases to their histone substrates (nucleosomal DNA-dependent)
• component of several complexes which regulate chromatin metabolism, including:
  • type B histone acetyltransferase complex
  • histone deacetylase core complex (HDAC)
  • nucleosome remodeling & histone deacetylase complex (NuRD complex)
  • PRC2/EED-EZH2 complex
  • nucleosome remodeling factor complex (NURF complex)
• binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin
• interacts with the viral protein-binding domain of the retinoblastoma protein (RB1)
• interacts with CREBBP; this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP
• interacts with BRCA1, HDAC7 & SUV39H1

Structure

• belongs to the WD repeat RBAP46/RBAP48/MSI1 family
• contains 6 WD repeats

Compartment

nucleus

More general terms

• retinoblastoma-binding protein
• WD repeat protein family
• phosphoprotein

Component of

• sin3 repressor complex
• histone acetyltransferase complex type B
• histone deacetylase (HDAC) core complex
• nucleosome remodeling & histone deacetylation (NuRD) complex
• Polycomb group multiprotein PRC2 complex; PRC2/EED-EZH2 complex; EZH2 histone methyltransferase complex (PcG)
• nucleosome-remodeling factor complex (NuRF complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5931
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5931
• OMIM: https://mirror.omim.org/entry/602922
• UniProt: http://www.uniprot.org/uniprot/Q16576.html