zinc finger protein AEBP2 (adipocyte enhancer-binding protein 2, AE-binding protein 2, AEBP2)

Function

• DNA-binding transcriptional repressor
• may interact with & stimulate activity of the PRC2 complex, which methylates Lys-9 & Lys-27 residues of histone H3
• self-associates
• interacts with EED, EZH2, RBBP4 & SUZ12
• may also interact with RBBP7

Structure

• belongs to the AEBP2/jing C2H2-type Zn+2-finger family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus (probable)

Alternative splicing

named isoforms=3

More general terms

• nuclear protein
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1215
• UniProt: http://www.uniprot.org/uniprot/Q6ZN18.html