polycomb protein SUZ12 (suppressor of zeste 12 protein homolog, joined to JAZF1 protein, chromatin precipitated E2F target 9 protein, ChET 9 protein, SUZ12, CHET9, JJAZ1, KIAA0160)
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Function
- polycomb group (PcG) protein.
- component of the PRC2 complex, which methylates Lys-9 & Lys-27 residues of histone H3
- induced by E2F1 transcription factor
Structure
- belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
- contains 1 C2H2-type zinc finger
Compartment
Pathology
- chromosomal translocation t(7;17)(p15;q21) with JAZF1 generates JAZF1-SUZ12 oncogene (N-terminus of JAZF1 & C-terminus of SUZ12) found in endometrial stromal tumors
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q15022.html
- ↑ Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/JJAZ1ID41039ch17q11.html