cyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b; p15INK4B; multiple tumor suppressor 2; MTS-2 (CDKN2B, MTS2)
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Function
- p15ink4B & related p16ink4 preferentially inhibit CDK4 & CDK6-cyclin complexes[1]
- heterodimer of CDKN2B with CDK4 or CDK6
- p15ink4B is an effector of TGF-beta induced cell-cycle arrest, thus may be involved in the same pathway as p27Kip1[2]
Structure
- belongs to the CDKN2 cyclin-dependent kinase inhibitor family
- contains 4 ANK repeats
Pathology
- defects in CDKN2B are involved in tumor formation
Polymorphism
- genetic variations in CDKN2B may underlie susceptibility to uveal melanoma
More general terms
- phosphoprotein
- anti-oncoprotein (tumor suppressor protein)
- cyclin-dependent kinase inhibitor (CDKI, CDKN)
- ankyrin repeat domain protein (ANKRD)
- human longevity protein
References
- ↑ 1.0 1.1 Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7877684
- ↑ 2.0 2.1 Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1030
- ↑ UniProt http://www.uniprot.org/uniprot/P42772.html
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/cdkn2b/