histone-lysine N-methyltransferase EZH1; ENX-2; enhancer of zeste homolog 1 (EZH1, KIAA0388)

Function

• polycomb group (PcG) protein
• catalytic subunit of the PRC2/EED-EZH1 complex, which methylates Lys-27 of histone H3, leading to transcriptional repression of the affected target gene(s)
• required for embryonic stem cell derivation & self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity

Structure

• belongs to the histone-lysine methyltransferase family, EZ subfamily
• contains 1 SET domain

Compartment

• nucleus
• colocalizes with trimethylated Lys-27 of histone H3

Alternative splicing

named isoforms=5

More general terms

• transcriptional silencer (transcriptional repressor)
• methyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2145
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2145
• OMIM: https://mirror.omim.org/entry/601674
• UniProt: http://www.uniprot.org/uniprot/Q92800.html