PRC2/EED-EZH1 complex

Function

• methylates Lys-27 of histone H3, leading to transcriptional repression of the affected target genes
• able to mono-, di- & trimethylate Lys-27 of histone H3
• required for embryonic stem cell derivation & self-renewal

Structure

• subunits include EED, EZH1, SUZ12, RBBP4 & AEBP2
• EZH1 is catalytic subunit

Expression

• less abundant than the PRC2/EED-EZH2 complex

More general terms

• molecular complex

Additional terms

• Polycomb group multiprotein PRC1 complex (PcG PRC1 complex, hPRC-H, PcG repressive complex 1)
• Polycomb group multiprotein PRC2 complex; PRC2/EED-EZH2 complex; EZH2 histone methyltransferase complex (PcG)