histone methyltransferase (HMT) complex; SET1 complex

Function

• probably several different complexes
  • one specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated (SET1 complex)
• another specifically mediates dimethylation & trimethylation of Lys-4 of histone H3

Structure

• subunits:
  • (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L & CXXC1/CFP1
  • RBBP5, ASH2L, SET1, SET2 & KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 & KMT2B/MLL

More general terms

• molecular complex
• histone N-methyltransferase

More specific terms

• menin-associated histone methyltransferase complex
• Set1/Ash2 histone methyltransferase (HMT) complex