Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein, ASH2L)

Function

• component of the Set1/Ash2 histone methyltransferase complex
• transcriptional regulator (putative)
• role in hematopoiesis (putative)
• interacts with HCFC1

Structure

• contains 1 B30.2/SPRY domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• ubiquitously expressed
• predominantly expressed in adult heart & testis & fetal lung and liver
• barely detectable expression in adult lung, liver, kidney, prostate, & peripheral leukocytes

More general terms

• protein subunit
• zinc finger protein

Component of

• Set1/Ash2 histone methyltransferase (HMT) complex

Database

• OMIM: https://mirror.omim.org/entry/604782
• UniProt: http://www.uniprot.org/uniprot/Q9UBL3.html