retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3)

Function

• binds preferentially to unphosphorylated Rb protein
• component of the SET1 complex
• component of MLL-complex
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 6 WD repeats

Compartment

nucleus

Expression

ubiquitously expressed

More general terms

• phosphoprotein
• retinoblastoma-binding protein
• WD repeat protein family

Component of

• ASC-2/NCOA6 complex (MLL2/MLL3 complex, ASCOM complex)
• Set1/Ash2 histone methyltransferase (HMT) complex

Database

• OMIM: https://mirror.omim.org/entry/600697
• UniProt: http://www.uniprot.org/uniprot/Q15291.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5929