CpG-binding protein; PHD finger & CXXC domain-containing protein 1; CXXC finger protein 1 (CXXC1, CGBP, PCCX1, PHF18)

Function

• transcriptional activator
• binding specificity for unmethylated CpG motifs
  • preference for CpGG
• may be regulated by proteolysis
• component of the SET1 complex
• interacts with SETD1A
• interacts with ZNF335

Structure

• the acidic domain carries the potential to activate transcription
• contains 1 CXXC-type Zn+2 finger
• contains 1 PHD-type Zn+2 finger

Compartment

• nuclear speckles
• associated with euchromatin
• during mitosis, excluded from condensed chromosomes

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• nuclear protein
• zinc finger protein
• phosphoprotein

Additional terms

• CpG island, GC-rich element or GC box

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30827
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:30827
• OMIM: https://mirror.omim.org/entry/609150
• UniProt: http://www.uniprot.org/uniprot/Q9P0U4.html