zinc finger protein 335; NRC-interacting factor 1; NIF-1 (ZNF335)

Function

• may regulate transcriptional activation through NCOA6
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with NCOA6,
• does not interact with ligand-bound nuclear hormone receptors, including ESR1, THRA, RARA, RXRA, GCCR or PPARA

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 13 C2H2-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in skeletal muscle, thymus, placenta & blood > colon, kidney lung > small intestine, heart, liver, brain

More general terms

• C2H2 type zinc finger protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=63925
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:63925
• OMIM: https://mirror.omim.org/entry/610827
• UniProt: http://www.uniprot.org/uniprot/Q9H4Z2.html