retinoic acid receptor RXR-alpha; retinoid X receptor alpha; nuclear receptor subfamily 2 group B member 1 (RXRA, NR2B1)
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Function
- nuclear hormone receptor
- involved in the retinoic acid response pathway
- binds 9-cis retinoic acid (9C-RA)
- ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer
- sumoylated on Lys-108; sumoylation negatively regulates transcriptional activity
- desumoylated specifically by SENP6
- homodimer or forms a heterodimer with PPAR-gamma (adipocyte-specific transcription factor ARF6)
- interaction with NCOA3 & NCOA6 coactivators, leads to transcription of target genes
- interacts with FAM120B (putative)
- interacts with SFPQ
- interacts with HCV core protein
- interacts with PELP1
- interacts with SENP6
- interacts with DNTTIP2
- interacts with RNF8
Structure
- composed of three domains:
- modulating N-terminal domain
- DNA-binding domain
- C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR2 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment
Expression
- highly expressed in liver
- also found in lung, kidney & heart
More general terms
References
- ↑ Sporn MB, Roberts AB. Interactions of retinoids and transforming growth factor-beta in regulation of cell differentiation and proliferation. Mol Endocrinol. 1991 Jan;5(1):3-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2017191
- ↑ Green S. Nuclear hormone receptors. Promiscuous liaisons. Nature. 1993 Feb 18;361(6413):590-1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8382343
- ↑ Wikipedia; Note: retinoid X receptor entry http://en.wikipedia.org/wiki/retinoid_X_receptor
- ↑ UniProt http://www.uniprot.org/uniprot/P19793.html