retinoic acid receptor alpha; RAR-alpha; nuclear receptor subfamily 1 group B member 1 (RARA, NR1B1)
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Function
- receptor for retinoic acid
- role in vertebrate development
- retinoic acid is a morphogen & a teratogen
- controls cell function by directly regulating gene expression
- interacts with CDK7 (putative)
- interacts with NCOA3 & NCOA6 coactivators, leading transcription of target genes
- interacts with NOCA7 (ligand-dependent)
- phosphorylated
- phosphorylation does not change during cell cycle
- phosphorylation on Ser-77 is crucial for transcriptional activity (putative)
Structure
- composed of three domains:
- modulating N-terminal domain
- DNA-binding domain
- C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR1 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment
Alternative splicing
named isoforms=2
Pathology
- chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia
- translocation t(11;17)(q32;q21) with ZBTB16/PLZF
- translocation t(15;17)(q24;q21) with PML
- translocation t(5;17)(q32;q21) with NPM
More general terms
References
- ↑ Sporn MB, Roberts AB. Interactions of retinoids and transforming growth factor-beta in regulation of cell differentiation and proliferation. Mol Endocrinol. 1991 Jan;5(1):3-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2017191
- ↑ Green S. Nuclear hormone receptors. Promiscuous liaisons. Nature. 1993 Feb 18;361(6413):590-1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8382343
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/RARAID46.html
- ↑ Wikipedia; Note: retinoic acid receptor entry http://en.wikipedia.org/wiki/retinoic_acid_receptor
- ↑ UniProt http://www.uniprot.org/uniprot/P10276.html