cyclin-dependent kinase-7 (CDK7) or p40M015

Function

• CDK7 is the mammalian homolog to the Xenopus protein kinase MO15
• CDK7 is 1-2 subunits of CDK-activating kinase (CAK) along with cyclin-H
• CAK is involved in controlling multiple cell cycle transitions phosphorylating many CDK/cyclin complexes
• activation of CAK occurs through phosphorylation of Ser-170 & Thr-176 (presumably on CDK7) by another serine/threonine kinase
• CAK is a component of TFIIH & in this form phosphorylates the C-terminal domain of the largest subunit of RNA polymerase 2
• activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 & CDK6 by Thr phosphorylation
• involved in cell cycle control & in RNA transcription by RNA polymerase 2
• expression & activity are constant throughout the cell cycle
• associates primarily with cyclin H & MAT1 to form the CAK complex
• interacts with PUF60
• inactivated by phosphorylation
• phosphorylation of Ser-164 during mitosis inactivates the enzyme
• phosphorylation of Thr-170 is required for activity

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
• contains 1 protein kinase domain

Compartment

nucleus

Expression

ubiquitous

More general terms

• cyclin-dependent kinase (CDK)

Additional terms

• CDK7/cyclin H complex, CDK-activating kinase (CAK) or p34cdc2 activating kinase
• cyclin H (MO15-associated protein, CCNH)

Database

• UniProt: http://www.uniprot.org/uniprot/P50613.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1022
• OMIM: https://mirror.omim.org/entry/601955
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1022