zinc finger & BTB domain-containing protein 16; zinc finger protein PLZF; promyelocytic leukemia zinc finger protein; zinc finger protein 145 (ZBTB16, PLZF, ZNF145)

Function

• probable transcription factor
• may play a role in myeloid maturation & in development &/or maintenance of other differentiated tissues
• probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
• binds EPN1
• interacts with ZBTB32 & CUL3
• protein ubiquitination

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 1 BTB (POZ) domain
• contains 9 C2H2-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines & peripheral blood mononuclear cells
• also expressed in the ovary, & at lower levels, in kidney & lung
• induced by retinoic acid

Pathology

• chromosomal translocation t(11;17)(q32;q21) involving ZBTB16 with RARA may be a cause of acute promyelocytic leukemia

More general terms

• transcription factor (TF)
• Zinc finger & BTB domain containing protein
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7704
• OMIM: https://mirror.omim.org/entry/176797
• UniProt: http://www.uniprot.org/uniprot/Q05516.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7704