zinc finger & BTB domain-containing protein 32 (Fanconi anemia zinc finger protein, testis zinc finger protein, FANCC-interacting protein, ZBTB32, FAZF, TZFP)

Function

• DNA-binding protein
• binds to 5'-TGTACAGTGT-3' core sequence
• may bind CpG islands in association with PLZF
• transcriptional transactivator
• transcriptional repressor via preventing GATA3 from binding to DNA
• role in regulating differentiation & activation of helper T cells
• interacts with the N-terminal of FANCC
• interacts with ZBTB16
• interacts with GATA3

Structure

• belongs to the krueppel C2H2-type zinc-finger protein family
• contains 3 C2H2-type zinc fingers C-terminal zinc finger domain functions as a transcriptional transactivator

contains 1 BTB domain (POZ domain)

Compartment

nucleus, located in nuclear speckles

Expression

• predominantly expressed in testis
• some isoforms are ubiquitously expressed

More general terms

• C2H2 type zinc finger protein
• DNA-binding protein
• transcription factor (TF)

Database

• OMIM: https://mirror.omim.org/entry/605859
• UniProt: http://www.uniprot.org/uniprot/Q9Y2Y4.html