GATA binding factor-3; T-cell transcription factor GATA-3; trans-acting T-cell-specific transcription factor GATA-3 (GATA3)

Function

• transcriptional activator
• binds to the enhancer of the T-cell receptor alpha & T-cell receptor delta genes
• binds to the consensus sequence 5'-AGATAG-3'

Structure

contains 2 GATA-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

-expressed in T-cells & endothelial cells

Pathology

• defects in GATA3 are the cause of Barakat syndrome

More general terms

• GATA binding factor (transcription factor GATA)

Database

• UniProt: http://www.uniprot.org/uniprot/P23771.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2625
• OMIM: https://mirror.omim.org/entry/131320
• OMIM: https://mirror.omim.org/entry/146255
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2625