Fanconi anemia group C protein; protein FACC (FANCC, FAC, FACC)

Function

• DNA repair protein
• postreplication repair
• cell cycle checkpoint function
• interstrand DNA cross-link repair
• maintenance of normal chromosome stability
• component of multisubunit FA complex
• interacts with ZBTB32

Compartment

• nucleus, cytoplasm
• major form is nuclear
• minor form is cytoplasmic

Expression

ubiquitous

Pathology

• defects in FANCC are a cause of Fanconi anemia

More general terms

• nuclear protein
• protein subunit

Additional terms

• Fanconi anemia

Component of

• Fanconi anemia complementation group complex (FA complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2176
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2176
• OMIM: https://mirror.omim.org/entry/227645
• OMIM: https://mirror.omim.org/entry/227650
• UniProt: http://www.uniprot.org/uniprot/Q00597.html