menin-associated histone methyltransferase complex

Function

• KMT2B/MLL4 in the complex methylates Lys-4 of histone H3
• H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation
• interacts with POLR2A & POLR2B via MEN1

Structure

• subunits include: KMT2B/MLL4, ASH2L, RBBP5, WDR5, DPY30, MEN1

More general terms

• histone methyltransferase (HMT) complex; SET1 complex