WD repeat-containing protein 5; BMP2-induced 3-kb gene protein (WDR5, BIG3)

Function

• contributes to histone modification
• may position the N- terminus of histone H3 for efficient trimethylation at Lys-4
• part of the MLL1/MLL complex;
  • in the complex, it is involved in methylation & dimethylation at Lys-4 of histone H3
  • histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation
• may regulate osteoblasts differentiation
• interacts with HCFC1
• component of the ADA2A-containing complex
  • in the complex, it probably interacts directly with KAT2A, MBIP & CSRP2BP
• component of the SET1 complex
• core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 & MLL3/MLL4
  • each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 & MLL4), & the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, IN80C, KDM6A, KIAA1267, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 & TEX10
• interacts with MLL & RBBP5
• interacts with histone H3

Structure

• belongs to the WD repeat WDR5/wds family
• contains 7 WD repeats

Compartment

nucleus

More general terms

• WD repeat protein family
• phosphoprotein
• nuclear protein

Component of

• Set1/Ash2 histone methyltransferase (HMT) complex
• ADA2A-containing complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11091
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11091
• OMIM: https://mirror.omim.org/entry/609012
• UniProt: http://www.uniprot.org/uniprot/P61964.html