general control of amino acid synthesis protein 5-like 2; histone acetyltransferase GCN5; hsGCN5; STAF97 (GCN5L2, GCN5, HGCN5, KAT2A)

Function

• histone acetyltransferase
• promotes transcriptional activation
• acetylation of histones gives a specific tag for epigenetic transcription activation
• has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles
• interacts with EP300, CREBBP & ADA2
• component of the TFTC-HAT complex
• interacts with TRRAP. component of the STAGA transcription coactivator-HAT complex

Structure

• belongs to the GCN5 family
• contains 1 bromo domain
• contains 1 N-acetyltransferase domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in all tissues tested
• most abundant expression in ovary

Pathology

• in case of HIV-1 infection, GCN5L2 is recruited by the retroviral protein Tat
• regulates Tat's transactivating activity & may help inducing chromatin remodeling of proviral genes
• interacts with & acetylates HIV-1 Tat

More general terms

• histone acetyltransferase
• phosphoprotein

Component of

• TFTC-HAT complex (TATA-binding protein-free TAF complex, TBP-free TAFII complex, TFTC)
• STAGA transcription coactivator-HAT complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2648
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2648
• OMIM: https://mirror.omim.org/entry/602301
• UniProt: http://www.uniprot.org/uniprot/Q92830.html