PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein, PAXIP1, PAXIP1L, PTIP, CAGF28)

Function

• component of DNA damage response
• phosphoserine or phosphothreonine-specific binding
• recognizes substrates phosphorylated by the kinases ATM & ATR, in response to gamma irradiation
• role in PAX2-dependent transcriptional regulation (putative)
• role in early development, most probably in cell proliferation
• interacts with the C-terminal transactivation domain of PAX2 (putative)

Structure

• BRCT domains function as a single module & are necessary & sufficient for phospho-specific binding
• contains 5 BRCT domains

Compartment

nucleus, matrix side (putative)

Alternative splicing

named isoforms=5

More general terms

• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/608254
• UniProt: http://www.uniprot.org/uniprot/Q6ZW49.html