microspherule protein 1 (58 kD microspherule protein, cell cycle-regulated factor p78, MCRS2, MCRS1, MSP58)

Function

• modulates transcription repressor activity of DAXX by recruiting it to the nucleolus
• may be an inhibitor of TERT telomerase activity
• binds to NOL1, DAXX, PINX1, TERT & Herpes simplex virus ICP22

Structure

contains 1 FHA domain

Compartment

• nucleus, nucleolus
• in microspherules in the nucleolus

Alternative splicing

named isoforms=3

Expression

• detected in testis > spleen, thymus, prostate, uterus, small intestine, colon, leukocytes
• cell-cycle regulated: levels are highest early in S phase, not detectable in G2

More general terms

• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96EZ8.html