PIN2/TERF1-interacting telomerase inhibitor 1; liver-related putative tumor suppressor; Pin2-interacting protein X1; protein 67-11-3; TRF1-interacting protein 1 (PINX1 LPTL LPTS)

Function

• microtubule-binding protein essential for faithful chromosome segregation
• mediates TRF1 & TERT accumulation in nucleolus & enhances TRF1 binding to telomeres
• inhibits telomerase activity
• may inhibit cell proliferation & act as tumor suppressor
• interacts with MCRS1, TERT, TERF1, NCL/nucleolin, & the telomerase RNA
• telomerase inhibitor
• binds TERT, TERF1

Structure

• the TID (telomerase inhibiting domain) domain is sufficient to bind TERT & inhibit its activity the TBM domain mediates interaction with TERF1
• belongs to the PINX1 family
• contains 1 G-patch domain

Compartment

• nucleus, nucleolus, chromosome, telomere
• centromere, kinetochore
• localizes in nucleoli, at telomere speckles & to the outer plate of kinetochores
• localization to the kinetochore is mediated by its central region & depends on NDC80 & CENPE

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• expressed at low levels
• not detectable in a number of hepatocarcinoma cell lines

More general terms

• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54984
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54984
• OMIM: https://mirror.omim.org/entry/606505
• UniProt: http://www.uniprot.org/uniprot/Q96BK5.html