centromere protein-E (CENP-E, CENPE)

Function

• minus-end directed microtubule motor
• probable kinetochore motor
• accumulates just before mitosis at the G2 phase of the cell cycle
• probably important for chromosome movement &/or spindle elongation
• interacts with CENP-F, BUBR1 kinase & PRC1

Structure

• belongs to the kinesin-like protein family
• contains 1 kinesin-motor domain

Compartment

• kinetochore, spindle, centromere
• associates with kinetochores during congression
• relocates to the spindle midzone at anaphase
• quantitatively discarded at the end of cell division

Alternative splicing

named isoforms=3

More general terms

• adenosine triphosphatase (ATPase)
• guanosine triphosphatase (GTPase)
• prenyl protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q02224.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1062
• OMIM: https://mirror.omim.org/entry/117143