nucleolin; protein C23 (NCL)

Function

• nucleolin is the major nucleolar protein of growing eukaryotic cells
• it is found associated with intranucleolar chromatin & pre-ribosomal particles
• it induces chromatin decondensation by binding to histone H1
• it is thought to play a role in pre-rRNA transcription & ribosome assembly
• may play a role in the process of transcriptional elongation
• binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats
• interacts with APTX & NSUN2
• component of the SWAP complex
• component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 & CCNT1, RNA polymerase 2, SUPT5H, & NCL/nucleolin

Structure

contains 4 RRM domain (RNA recognition motif)s

Compartment

nucleus, nucleolus

More general terms

• phosphoprotein
• DNA-binding protein
• RNA-binding protein

More specific terms

• N-60

Component of

• SWAP complex

Database

• UniProt: http://www.uniprot.org/uniprot/P19338.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4691
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4691
• OMIM: https://mirror.omim.org/entry/164035