cyclin T1 (CCNT1)
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Function
- regulatory subunit of CDK9/cyclin T) complex
- transition from abortive to production elongation by phosphorylating the CTD of RNA pol 2 large subunit
- binds to transactivation domain of the HIV-1 nuclear transcriptional activator
- cofactor for HIV 2-Tat & simian immunodeficiency virus
- predominant cyclin associated with CDK9
Compartment
Expression
ubiquitously expressed
More general terms
References
- ↑ Wei P, Garber ME, Fang SM, Fischer WH, Jones KA. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell. 1998 Feb 20;92(4):451-62. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9491887
- ↑ UniProt http://www.uniprot.org/uniprot/O60563.html