cyclin-dependent kinase-9 (CDK9, serine/threonine protein kinase PITALRE, CDC2L4)

Function

• member of the cyclin-dependent kinase pair P-TEFb (CDK9/cyclin-T complex)
• associates with CCNT1/cyclin-T1 to form P-TEFb.
• associates with CCNK/cyclin-K
• CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II & can substitute for P-TEFb in vitro
• component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, & NCL/nucleolin
• component of the 7SK snRNP complex

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
• contains 1 protein kinase domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• cyclin-dependent kinase (CDK)

Component of

• 7SK SNRNP complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1025
• OMIM: https://mirror.omim.org/entry/603251
• UniProt: http://www.uniprot.org/uniprot/P50750.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1025