positive transcription elongation factor B (P-TEFB, CDK9/cyclin T complex)

Function

• facilitates transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase 2 (RNAP2)
• forms a complex with AFF4/AF5Q31
• interacts with DSIF complex

Structure

• subunits: CDK9, cyclin-T (CCNT1 or CCNT2)

More general terms

• molecular complex

Additional terms

• elongin (SIII, transcription elongation factor B, TEFB)