cyclin T2 (CCNT2)

Function

• regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex (P-TEFB)
• associates with CDK9 to form P-TEFB
• isoform A & isoform B interact with HIV-2 & SIV Tat
• does not bind efficiently to the transactivation domain of the HIV-1 Tat

Structure

belongs to the cyclin family, cyclin C subfamily

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

More general terms

• cyclin T (positive transcription elongation factor B, P-TEFB)
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603862
• UniProt: http://www.uniprot.org/uniprot/O60583.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=905