HIV Tat-specific factor 1 (HTATSF1, Tat-SF1)

Function

• general transcription factor
  • transcriptional elongation
  • stimulatory effect of splicing on transcriptional elongation
• component of Tat-SF complex
• interacts with TCERG1/CA150, snRNPs

Compartment

nucleus

Expression

widely expressed

Pathology

• up-regulated by the HIV-1 proteins NEF & gp120
• acts as a cofactor required for Tat-enhanced transcription of HIV1

More general terms

• phosphoprotein
• general transcription factor (basal transcription factor, transcription initiation factor)

Component of

• Tat-SF complex

Database

• OMIM: https://mirror.omim.org/entry/300346
• UniProt: http://www.uniprot.org/uniprot/O43719.html