transcription elongation regulator 1; TATA box-binding protein-associated factor 2S; transcription factor CA150 (TCERG1, CA150, TAF2S)

Function

• transcription factor
• binds RNA polymerase 2 & inhibits elongation of transcripts from target promoters
• regulates transcription elongation (TATA box-dependent)
• necessary for TAT-dependent activation of the HIV1 promoter
• binds formin (putative)
• binds RNA polymerase 2, HD & SF1

Structure

• the FF domains
  • bind the phosphorylated C-terminus of RNA polymerase 2 largest subunit
  • probably mediate interaction with HTATSF1
  • preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5)
• the WW domains bind Pro-rich domains
• contains 6 FF domains
• contains 3 WW domains

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• detected in brain neurons

Pathology

• up-regulated in brain tissue from patients with Huntington disease

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10915
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10915
• OMIM: https://mirror.omim.org/entry/605409
• UniProt: http://www.uniprot.org/uniprot/O14776.html