7SK SNRNP complex

Function

• mediates ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling

Structure

• subunits: composed of P-TEFb (CDK9 & CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins & 7SK & U6 snRNAs

More general terms

• molecular complex