protein HEXIM2 (hexamethylene bis-acetamide-inducible protein 2, HEXIM2)

Function

• transcriptional regulator
• functions as a general RNA polymerase 2 transcription inhibitor
• in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase 2 phosphorylation & subsequent transcriptional elongation
• homooligomer & heterooligomer with HEXIM1; probably dimeric
• component of the 7SK snRNP complex

Structure

• coiled-coil domain mediates oligomerization
• belongs to the HEXIM family

Compartment

nucleus

Expression

• ubiquitously expressed
• higher expression in testis
• HEXIM1 & HEXIM2 are differentially expressed
• up-regulated by HMBA (hexamethylene bisacetamide) (at protein level)

More general terms

• nuclear protein
• phosphoprotein

Component of

• 7SK SNRNP complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q96MH2.html