telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1 (TERF1, PIN2, TRBF1, TRF1)

Function

• involved in mitotic spindle checkpoint/mitotic regulation
• binds the telomeric double-stranded TTAGGG repeat & negatively regulates telomere length
• important for maintaining mitotic checkpoint in response to DNA damage
• interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2, MAPRE1
• phosphorylated preferentially on Ser-219 by ATM kinase in response to ionizing DNA damage.
• ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA
• found in a complex with POT1, TINF2 & TNKS1.

Structure

• homodimer
• the acidic N-terminal domain binds to the ankyrin repeats of TNKS1 & TNKS2
• C-terminal domain binds microtubules

Compartment

• nuclear
• colocalizes with telomeric DNA in interphase & metaphase cells
• located at chromosome ends during metaphase
• associates with the mitotic spindle

Expression

• highly expressed & ubiquitous
• isoform Pin2 predominates
• Pin2 expression is tighly regulated during the cell cycle
• levels of Pin2 are low in G1 & S phase & increase during G2 phase & mitosis

Notes

• Pin2 is identical to TRF1 except for a 20 amino acid deletion

More general terms

• telomeric repeat binding factor
• peptidyl-prolyl cis/trans isomerase, NIMA-interacting (Pin)
• phosphoprotein

Additional terms

• PIN2/TERF1-interacting telomerase inhibitor 1; liver-related putative tumor suppressor; Pin2-interacting protein X1; protein 67-11-3; TRF1-interacting protein 1 (PINX1 LPTL LPTS)

Component of

• double-stranded telomeric DNA-binding TRF1 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7013
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7013
• OMIM: https://mirror.omim.org/entry/600951
• UniProt: http://www.uniprot.org/uniprot/P54274.html