POT1 protein (protection of telomeres 1, POT1-like telomere end-binding protein)

Function

• putative telomere end binding protein involved in telomere stability & maintenance
• component of the telomerase ribonucleoprotein complex
• component of the double-stranded telomeric DNA-binding TRF1 complex
• acts as a single-stranded telomeric DNA-binding protein
  • binds 2 or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand)
  • specifically binds a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence
  • binds telomeric single-stranded sequences internally or at proximity of a 3'end
• activity is TERT dependent
• does not increase TERT activity
• binds single-stranded telomeric DNA as a monomer
• bound in a complex with TERF1, TINF2 & TNKS1
• interacts with TNKS1

Structure

homodimer or homooligomer

Compartment

nuclear; colocalizes with telomeric DNA

Expression

ubiquitous

More general terms

• telomeric repeat binding factor

Component of

• double-stranded telomeric DNA-binding TRF1 complex
• telomerase

Database

• OMIM: https://mirror.omim.org/entry/606478
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25913
• UniProt: http://www.uniprot.org/uniprot/Q9NUX5.html