microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1, end-binding protein 1, EB1, MAPRE1)

Function

• role in microtubule polymerization & spindle function by stabilizing microtubules & anchoring them at centrosomes
• role in cell migration (putative)
• interacts with DCTN1, DCTN2, DIAPH1, DIAPH2, TERF1 & dynein intermediate chain
• binds to C-terminal domain of APC
• interacts with CLASP1 & CLASP2

Structure

• homodimer
• composed of two functionally independent domain
  • N-terminal domain forms an hydrophobic cleft involved in microtubule binding
  • C-terminal domain is involved in the formation of mutually exclusive complexes with APC & DCTN1
• belongs to the MAPRE family
• contains 1 CH domain (calponin-homology domain
  • contains 1 EB1 C-terminal domain

Compartment

• cytoplasm
• associated with microtubule network at the growing distal tip of microtubules.
• also enriched at the centrosome

More general terms

• microtubule-associated protein (MAP)
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603108
• UniProt: http://www.uniprot.org/uniprot/Q15691.html